Which of the following would provide longer-acting pain relief in mice?

Which of the following would provide longer-acting pain relief in mice?

• A. Carprofen
• B. Buprenorphine
• C. Meloxicam
• D. Ketoprofen

Answer: (A)

Duration of pain relief in mice depends on how long the drug stays active in the body and continues to blunt pain pathways. Carprofen, an NSAID, tends to provide longer-lasting analgesia in mice because its pharmacokinetic profile yields a longer duration of effective COX inhibition after a single dose. This means prostaglandin production remains suppressed for a longer period, giving sustained relief. In contrast, buprenorphine, while potent, usually delivers analgesia for a shorter window in mice and can be more variable between individuals. The other NSAIDs listed (meloxicam and ketoprofen) also provide useful analgesia but typically require more frequent dosing or have a shorter duration at common analgesic doses in mice. Therefore, carprofen is the option associated with longer-acting pain relief.

Duration of pain relief in mice depends on how long the drug stays active in the body and continues to blunt pain pathways. Carprofen, an NSAID, tends to provide longer-lasting analgesia in mice because its pharmacokinetic profile yields a longer duration of effective COX inhibition after a single dose. This means prostaglandin production remains suppressed for a longer period, giving sustained relief.

In contrast, buprenorphine, while potent, usually delivers analgesia for a shorter window in mice and can be more variable between individuals. The other NSAIDs listed (meloxicam and ketoprofen) also provide useful analgesia but typically require more frequent dosing or have a shorter duration at common analgesic doses in mice. Therefore, carprofen is the option associated with longer-acting pain relief.